1
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- The World Health Organization estimates that in the next decade 300
million more people will become infected, that 90 million people will
develop the disease, and 30 million people will die from it. TB
currently kills more adults each year than AIDS, malaria and tropical
diseases combined, and almost 170,000 children (see the WHO Report on
Global Tuberculosis Control).
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2
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- Reduces incidence 54-88%
- 12 month course of medication
- Prevent progression to clinical disease
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3
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4
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- Give with B6
- Single daily dosing
- Empty stomach if possible
- 6-9 months
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5
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- Reddish discoloration
- Rifampin and INH in combination eliminate TB from sputum and produce
clinical improvement
- Take on empty stomach
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6
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- N & V & diarrhea
- Neurotoxicity 8th cranial nerve (575)
- Hepatotoxicity
- Hypersensitivity
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7
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- Inhibit viral DNA reproduction
- H. zoster & H simplex
- Q8h x 5 or 7d
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8
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- Nucleoside Reverse Transcriptase Inhibitors
- Non-Nucleoside Reverse Transcriptase Inhibitos
- Protease Inhibitors
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9
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- Substitutes for thymidine
- Inhibits reverse tansciptase
- Prevention
- Slows progression
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10
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- Treat advanced disease
- Inhibit viral replication
- Used for synergistic effect
- Pg 586
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11
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- Pg 586
- Drug interactions pg 587
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12
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