Prototype
Acetominophen
n
Does not cause N & V or GI bleeding
n
Does not interfere with clotting
n
Lacks anti-inflammatory activity
n
Metabolized in liver
n
Approximately 4 % is a toxic metabolite normally inactivated by conjoining with glutathione and excreted in a in acute or chroni or overdose glutathione may be depleted causing liver damage or fatal necrosis.
ETOH amplifies the effect