Agonists
Prototype: Morphine Sulfate
n
Morphine and morphine like drugs
n
Activity at Mu, Kappa, & ??? Delta receptors
n
Severe & Chronic Pain
n
IV, IM, SQ, Suppository, Epidural,&, PO
n
Impaired kidney function may cause prolonged
drug action and accumulation
n
Nonceiling drug
Table 6-1
Mu, Kappa, Delta Pg 73
After IV 10-20 minutes for respiratory depression and analgesia
Ineffective pain management…morphine is doc with severe pain
Nonceiling…no upperlimit don dosage for tolerance
May give non opiods with opioids in chrnic pain