|
|
|
PO first pass metabolism
requires that the doses are very high, metabolized in the liver
|
|
Liver impairment may
interfere with metabolism and kidney may interfere with excretion
|
|
Generally small to moderate
doses relieve constant dull pain moderate to large for intermittent sharp
pain
|
|
Give smaller dose if
effective
|
|
More effective at the onset
of pain parentaerally
|
|
Chronic on regular schedule
|
|
Give before coughing and
deepbreathing or dressings
|
|
Long term use may be for
malignant disease
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|
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