Immune system not
fully activated until after birth results in failure of newborns
inflammatory response result in failure to recognize, localize and destroy
invasive bacteria.
S&S of
infection are subtle.Fever not a
reliable indicator of infection.Hypothermia ia a more reliable sign of infection.
Immunoglobulins-
IgG crosses placenta and gives passive acquired immunity
IgM produced by
fetus usually response to blood group antigens, gram-negative enteric
organisms and some viruses in mom.Suggest exposure to TORCH infections