Penicillin/Beta Lactamase
Inhibitor Combinations
Prototype: Amoxicillin & Clavulanate
(Augmentin)
n
n
Inactivate beta-
lactamase enzymes
n
Protects PCN and
extends spectrum
n
Available PO
Resistance to beta lactam antibiotics through penicillinase and cephalosporinase are enzymes that act on pcn