|
|
|
HbA1C
Predicts Coronary Heart Disease in Type 2 Diabetes
|
|
•A prospective study by Kuusisto and coworkers
evaluated the effect of metabolic control on coronary heart disease (CHD)
events during a 3½-year period in 1,069 nondiabetic elderly patients and 229
with type 2 diabetes in Finland.
|
|
•Metabolic control was determined according to
HbA1C concentrations. The incidence of mortality attributed to CHD
increased significantly (P<0.01) in patients with HbA1C
concentrations in the highest tertile (>7.9%) compared with patients with
concentrations lower than 6%.
|
|
•The incidence of all CHD events was also
significantly higher (P<0.05) among patients with the highest
tertile HbA1C concentrations than that among patients in the
lowest tertile of HbA1C. The impact of type 2 diabetes on the
morbidity and mortality associated with CHD was more pronounced in women than
in men.
|
|
•The results of this study demonstrate that
metabolic control of type 2 diabetes and the duration of diabetes are
important predictors of CHD in elderly subjects, particularly women.
|
|
Kuusisto J et
al. Diabetes. 1994;43:960-967.
|
|
|