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Cephalosporins
Prototype: Cephalexin (Keflex)
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Broad spectrum
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First generation
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Respiratory, soft tissue,
bones, urinary tract, and
bloodstream infections
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Tx pcn resistant GC
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Contraindicated with prior
severe
anaphylactic
reaction to PCN
•
•
•
Clinically important for gram negative infections
Cocci pcn cheaper and more effective
Chemically similar to pcn incidence of cross-sensitivity is low especially with delayed reactions
Pg 519 med error
There are many, many cephalosporins 4 generations, Many sound alike